Ethnoprimatology is a research approach used to study the diverse ways that human and other primates’ lives and livelihoods intersect. Our objective in this chapter is to illustrate the use and value of ethnoprimatology in studying human-primate interfaces across both time and space. We begin by clarifying how human-primate interfaces occur across a gradient from rural to urban landscapes and illustrate how the ethnoprimatological approach is implemented. We showcase how ethnoprimatology’s theoretical and methodological landscape has expanded since its emergence in the late 1990s to include the integration of frameworks and tools from the natural and social sciences and the humanities. To illustrate the practice of ethnoprimatology, we highlight research conducted on the human-primate interface across three geographies of human-primate encounters: tourism sites, urban and peri-urban settings, and agroecosystems. We conclude by showing how the human-primate interconnections uncovered by ethnoprimatology have important implications for conservation, management of human-primate interfaces, and the sustainable coexistence of multispecies communities in the contemporary era.