The importance of increasing crop production in light of extreme events due to climate change and a human population growth projected to reach nine billion this century is a major challenge. Endophytic fungi and bacteria offer a novel approach to enhance agricultural productivity while reducing environmental costs. Endophytes have been shown to aid several plant growth processes. Endophytes could also help increase crop production and reduce yield losses by improving resistance to both biotic and abiotic stresses. With climate change projected to have drastic impact on agriculture especially in arid and semi-arid regions, endophytes could play a major role in sustaining agricultural production. In concert with other novel agronomic technologies and management, endophytes could help in mitigating the impacts of climate change. This review focuses on the ability of endophytes in promoting growth as well as in imparting stress tolerance in the context of climate change.