Bhardwaj, Nivedita and Kumar Sharma, Vivek and Tripathi, Nancy and Pimpre, Kavita and Sonti, Rajesh and Gudasalamani, Ravikanth and Koch, Biplob and Jain, Shreyans K. (2024) Isolation of cytotoxic cycloartane triterpenoids from Dysoxylum malabaricum. New Journal of Chemistry, 48 (9).

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Abstract

Dysoxylum malabaricum, a member of the Meliaceae family, is native to the Western Ghats region in India.1,2 Triterpenoids constitute the predominant category of phytochemicals within this plant genus. Limited research has been conducted on this particular species, leaving significant uncharted territory for further exploration and investigation. The genus yielded a range of bioactive triterpenoids upon isolation.3 Some medicinally essential alkaloids, viz. rohitukine, and camptothecin have been isolated from Dysoxylum binectariferum. The rohitukine inspired the discovery of potent CDK-inhibitor drugs like flavopiridol and rivicicilib.4,5 Moreover, other than alkaloids, different triterpenoids and glycosides were isolated from this genus showing anti-inflammatory, anti-malarial, anti-tumor, cytotoxic, anti-depressant, and antimicrobial action.

Item Type: Article
Additional Information: Copyright of this article belongs to The Royal Society of Chemistry and the Centre National de la Recherche Scientifique 2024.
Subjects: A ATREE Publications > G Journal Papers
Divisions: SM Sehgal Foundation Centre for Biodiversity and Conservation > Biodiversity Monitoring and Conservation Planning
Depositing User: Ms Library Staff
Date Deposited: 26 Jun 2026 06:14
Last Modified: 26 Jun 2026 06:14
URI: http://archives.atree.org/id/eprint/1533

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